Preimplantation Genetic Testing for Chromosomal Defects Improves IVF Outcomes in Patients with Recurrent Pregnancy Loss


Preimplantation Genetic Testing for Chromosomal Defects Improves IVF Outcomes in Patients with Recurrent Pregnancy Loss

Philadelphia, PA- In the largest study to date examining the usefulness of preimplantation genetic testing for aneuploidy (PGT-A), for patients with recurrent pregnancy loss (RPL), Rutgers researchers report that PGT-A is associated with significant improvements in live birth, clinical pregnancy, and spontaneous abortion rates, especially in women over the age of 35.

The retrospective cohort study, using nationwide United States data from SART-CORS, was restricted to patients using their own eggs and having frozen embryo transfer (FET) in order to better compare outcomes. RPL patients had had three or more pregnancy losses before undergoing the cycles included in the study.  The researchers analyzed outcomes of 24,007 FET cycles with PGT-A, comparing them to 43,811 control FET cycles without PGT-A in the RPL patient population for the years 2010 through 2016.

The primary outcome was the live birth rate (LBR).  In patients under 35, the LBR for FET with PGT-A was 55.3%, compared to 48.6 % without PGT-A.  For patients 35 and older whose embryos were tested, the live birth rate was 52.5%, compared to 35.3% in controls. Correspondingly, in both age groups, clinical pregnancy rates were higher and spontaneous abortion rates were lower in cycles that included PGT-A.

Amy Sparks, PhD, President of the Society for Assisted Reproductive Technology, commented, “This study provides evidence for the benefit PGT may offer patients who have been battling recurrent pregnancy loss. When counseling patients with this diagnosis, IVF with PGT for euploid embryo selection is an option that should be part of the discussion.”

O-76 Bhatt et al, “Pregnancy Outcomes Following In Vitro Fertilization Frozen Embryo Transfer (IVF-FET) with or without Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Women with Recurrent Pregnancy Loss (RPL): A SART/CORS Study”


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