Maternal Pre-Diabetes Is Associated with Sex Chromosome Abnormalities in IVF Embryos

HIGHLIGHTS FROM THE AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE’S 2019 SCIENTIFIC CONGRESS & EXPO
15
Oct

Maternal Pre-Diabetes Is Associated with Sex Chromosome Abnormalities in IVF Embryos

Philadelphia, PA- Embryos from pre-diabetic patients are more than twice as likely to have sex chromosome aneuploidies than embryos from patients with normal levels of glycated hemoglobin.

Today at the 75th annual Scientific Congress and Expo of the American Society for Reproductive Medicine, researchers from Northwell Fertility (NY) presented data from a retrospective cohort study, the first to show the risk of aneuploidy correlated with glycated hemoglobin levels in the pre-diabetic range.

The researchers reviewed ART cycles done at the center between 2013 and 2017 incorporating preimplantation genetic testing for aneuploidies (PGT-A). They excluded cycles for patients classified as diabetic.

Blastocysts from 393 patients were analyzed. Three hundred and twenty patients had normal levels of glycated hemoglobin and 73 had levels in the prediabetic range.

Pre-diabetes was significantly correlated with the incidence of sex-chromosome aneuploidy, but not with autosomal aneuploidies.  Slightly more than half of the embryos from non-diabetic patients (52%) and pre-diabetic patients (54.6%) had abnormal results for non-sex chromosomes. However, abnormalities in the X and Y chromosomes were found more frequently in the embryos of pre-diabetic patients (7.09%) than in the embryos of patients classified non-diabetic (3.23%).

Maternal age, and hormone levels (FSH and AMH) were not correlated with aneuploidy.

ASRM Past President Christos Coutifaris, MD, PhD commented, “Diabetes and pre-diabetes have subtle effects on reproduction. Further studies are needed to get a better grasp on this finding, but patients should be counseled on the impact these conditions may have on their efforts to conceive and the ways they can mitigate them.”

O-116 Abittan et al, “Is There a Predisposition to Embryonic Aneuploidy in Pre-Diabetic Patients?” 

ASRM is a multidisciplinary organization dedicated to the advancement of the science and practice of reproductive medicine. The Society accomplishes its mission through the pursuit of excellence in education and research and through advocacy on behalf of patients, physicians, and affiliated health care providers. The Society is committed to facilitating and sponsoring educational activities for the lay public and continuing medical education activities for professionals who are engaged in the practice of and research in reproductive medicine. www.asrm.org