Tessa J. Roseboom, PhD, Amsterdam UMC, Amsterdam, Netherlands:
Herbert H. Thomas Plenary Lecture: How the Early Environment Shapes Later Health: The Fundamental Importance of a Good Start in Life
Every living creature is sensitive to its environment, particularly during the earliest phases of growth and development. Studies of men and women conceived during the wartime famine of 1944-45 in the Netherlands have shown that sub-optimal conditions during embryonic development can have lasting consequences for health of individuals that impacts society. In this lecture, the lessons learned from these historical studies will be put into a human biology perspective that highlights the relevance for reproductive medicine today and the health of generations to come.
Xiaoliang Sunney Xie, PhD, Peking University, Beijing, China:
Camran Nezhat, MD Lectureship in Innovations in Medicine: Non-Invasive Preimplantation Genetic Testing for Aneuploidy, Monogenic and Multigenic Diseases
Preimplantation genetic testing for aneuploidy (PGT-A) with trophectoderm (TE) biopsy is widely applied in in vitro fertilization to identify aneuploid embryos. However, potential safety concerns regarding biopsy and restrictions to only those embryos suitable for biopsy pose limitations. In addition, embryo mosaicism gives rise to false positives and false negatives in PGT-A because the inner cell mass (ICM) cells, which give rise to the fetus, are not tested. We report a non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) in the spent culture media by measuring the copy numbers of cell-free DNA from the ICM only. Less prone to errors associated with embryo mosaicism, this method is more reliable than trophectoderm-biopsy PGT-A. Meanwhile, we also have demonstrated niPGT-A in the spent culture for monogenic and polygenic diseases by high-precision detection of point mutations in the cell free deoxyribonucleic acid (DNA) through linkage analyses.
Join us for this fun event featuring our awards presentation and promising to be a lot of fun. Mark the evening of Friday, October 16th on your calendar and stay tuned for registration and addition details.
The Run for Reproductive Health Returns this Year
Run, walk, bile or Paleton for a great cause with a team or solo October 1- 15. Details and registration coming later this week.
Participate in Virtual Quest
During this year's Congress, participate in our Virtual Quest scavenger hunt for an opportunity to win exciting prizes. If you enjoy the passport game at our in-person meetings, you won't want to miss this! Details coming soon.