Xiaoliang Sunney Xie, PhD, Peking University, Beijing, China Camran Nezhat, MD Lectureship in Innovations in Medicine: Non-Invasive Preimplantation Genetic Testing for Aneuploidy, Monogenic and Multigenic Diseases
Preimplantation genetic testing for aneuploidy (PGT-A) with trophectoderm (TE) biopsy is widely applied in in vitro fertilization to identify aneuploid embryos. However, potential safety concerns regarding biopsy and restrictions to only those embryos suitable for biopsy pose limitations. In addition, embryo mosaicism gives rise to false positives and false negatives in PGT-A because the inner cell mass (ICM) cells, which give rise to the fetus, are not tested. We report a noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) in the spent culture media by measuring the copy numbers of cell-free DNA from the ICM only. Less prone to errors associated with embryo mosaicism, this method is more reliable than trophectoderm-biopsy PGT-A. Meanwhile, we have also demonstrated niPGT-A in the spent culture for monogenic and polygenic diseases by high-precision detection of point mutations in the cell free deoxyribonucleic acid (DNA) through linkage analyses.
Jamie Krashin, MD, MSCR, University of New Mexico, NM, Antoinette Nguyen, MD, MPH, Emory University, Atlanta, GA and Bethany T. Samuelson Bannow, MD, Oregon Health and Science University, Portland, OR Hormones & Thrombosis: A Primer for Clinicians and Roadmap for Researchers
Hormones play an important role in preventing or optimally timing pregnancy, facilitating assisted reproductive technology, and improving the quality of life around menopause. However, many women are at increased risk of thrombosis because of underlying medical conditions such as systemic lupus erythematosus, prior thrombosis, hereditary or acquired thrombophilia, hypertension, obesity, and complicated diabetes mellitus. These women are also at increased risk of adverse events in pregnancy. Given the high U.S. prevalence of hypertension, obesity, and diabetes, managing hormonal therapy safely for these patients is crucial for clinicians. We will review the evidence for safety of use of hormones in clinical care including groups at risk for thrombophilia. We will provide resources for risk assessment and discuss strategies for conditions for which there is no evidence. We will discuss the quality of evidence and research gaps around hormone use and thrombophilia.
Nichole M. Barker, DO, Seattle Reproductive Medicine – Tacoma, Tacoma, WA, Lee Hullender Rubin, DAOM, Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, CA, Rachelle L. Mallik, MA, RD, LDN, The Food Therapist, LLC, Chicago, IL and Anne Judge, DNP, ARNP, WHNP-BC, Seattle Reproductive Medicine – Kirkland, Kirkland, WA Fertility Patient Support Strategies
The distress of infertility can be a significant barrier to continuing treatment and a tremendous burden with 25-60% reporting anxiety and depression symptoms. Physicians are generally unable to allot adequate time to patient support strategies during the initial consult. Patient distress may be addressed by a multidisciplinary approach to patient support. In this interactive session, we will identify patient support gaps in the initial consult, and present integrative strategies to support patients, reduce stress, improve diet and lifestyle, and enhance resilience.
ASRM's 2020 Gala: A Mask-R-Aid Ball
Join us for this fun event featuring our awards presentation and promising to be a lot of fun. Mark the evening of Friday, October 16th on your calendar and stay tuned for registration and addition details.
The Run for Reproductive Health Returns this Year
Run, walk, bike or Paleton for a great cause with a team or solo October 1- 15. Details and registration coming later this week.
Participate in a Virtual Quest
During this year's Congress, participate in our Virtual Quest scavenger hunt for an opportunity to win exciting prizes. If you enjoy the passport game at our in-person meetings, you won't want to miss this! Details coming soon.